Water → HCID 21474581, compound

HRID 274036Notes

Reaction equation

HRID 274036 reaction equation
C([N:3]([CH2:6][CH3:7])[CH2:4][CH3:5])C.[NH:8]1CCCC1.[C:13]([C:17]1[CH:18]=[C:19]([CH:33]=[CH:34][C:35]=1[O:36][CH3:37])[C:20]([O:22][CH2:23][C:24]1[CH:32]=[CH:31][C:27]([C:28](Cl)=[O:29])=[CH:26][CH:25]=1)=[O:21])([CH3:16])([CH3:15])[CH3:14].O>C1COCC1>[N:3]1([NH:8][C:28](=[O:29])[C:27]2[CH:31]=[CH:32][C:24]([CH2:23][O:22][C:20](=[O:21])[C:19]3[CH:33]=[CH:34][C:35]([O:36][CH3:37])=[C:17]([C:13]([CH3:16])([CH3:15])[CH3:14])[CH:18]=3)=[CH:25][CH:26]=2)[CH2:4][CH2:5][CH2:7][CH2:6]1

Participants

6

Reactant 4

HCID 962WaterHCID 8471TriethylamineHCID 31268PyrrolidineHCID 21474522HCID 21474522, compound

Product 1

HCID 21474581HCID 21474581, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

760 [l (5.5 mmol) of triethylamine, 450 μl (5.5 mmol) of pyrrolidine and 50 ml of THF are introduced into a round-bottomed flask. 1.8 g (5 mmol) of 4-(3-tertbutyl-4-methoxybenzoyloxymethyl)benzoyl chloride, dissolved in 50 ml of THF, are added dropwise and the mixture is stirred at room temperature for 4 h. The reaction medium is poured into water, the mixture is extracted with ethyl ether and the organic phase is separated after settling has taken place, dried over magnesium sulphate and evaporated.

Workup

  1. additionare added dropwise
  2. extractionthe mixture is extracted with ethyl ether
  3. customthe organic phase is separated after settling
  4. dry with materialdried over magnesium sulphate
  5. customevaporated

Sources & evidence

ORD record
ord-a7a4f19a8dff4282b57d914352a14182
Source dataset
uspto-grants-1995_02
Patent number
US05387594

Reaction notes

Loading…