Water → 2-Fluoro-6-phenylsulfonylpyridine

HRID 274183Notes

Reaction equation

HRID 274183 reaction equation
F[C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([F:8])[N:3]=1.[C:9]1([SH:15])[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[OH-:16].[Na+].[OH2:18]>[Br-].C([N+](CCCC)(CCCC)CCCC)CCC.C1(C)C=CC=CC=1>[F:8][C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([S:15]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=2)(=[O:18])=[O:16])[N:3]=1

Participants

7

Reactant 4

HCID 962WaterHCID 7969ThiophenolHCID 14798Sodium HydroxideHCID 739342,6-Difluoropyridine

Product 1

HCID 200921242-Fluoro-6-phenylsulfonylpyridine

Reagents, catalysts & solvents 2

HCID 74236Tetrabutylammonium BromideCatalystHCID 1140TolueneSolvent

Procedure

A mixture of 0.4 mol of 2,6-difluoropyridine, 0.6 mol of thiophenol, 0.6 mol of NaOH, 450 ml of water, 180 ml of toluene and 3.5 g of tetrabutylammonium bromide is refluxed for hours.

Workup

  1. temperatureis refluxed for hours

Sources & evidence

ORD record
ord-88e93e1dc42c487eb9a390e5b7e75ead
Source dataset
uspto-grants-1995_02
Patent number
US05389291

Reaction notes

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