Methyl chloroformate → HCID 15230492, compound

To a solution of 8-chloro-2-amino-1,2,3,4-tetrahydronaphthalene (250 mg, 1.38 mMol) in tetrahydrofuran (25 mL) was added triethylamine (0.38 mL, 2.76 mMol) followed by the careful addition of methyl chloroformate (0.26 mL, 2.76 mMol). The reaction mixture was stirred at room temperature for one-half hour. The reaction mixture was then diluted with 10% hydrochloric acid and extracted well with dichloromethane. The combined organic extracts were dried over sodium sulfate and concentrated in vacuo to give a viscous oil. The oil in tetrahydrofuran (5 mL) was added dropwise to a suspension of lithium aluminum hydride (110 mg, 2.76 mMol) in tetrahydrofuran (20 mL). The reaction mixture was stirred for three hours at room temperature and then one hour at reflux. The reaction mixture was then cooled to 0° C., and to it were added sequentially water (0.1 mL), 15% aqueous sodium hydroxide (0.1 mL) and water (0.3 mL). The suspension was then stirred at room temperature for two hours and then was filtered through a bed of Celite. The filtrate was concentrated in vacuo to give the title compound as a yellow viscous oil (240 mg 89%). The hydrochloride salt was formed and recrystallized (ethanol/diethyl ether) to give colorless crystals (m.p.=214°-215° C.).

1. extractionextracted well with dichloromethane
2. dry with materialThe combined organic extracts were dried over sodium sulfate
3. concentrationconcentrated in vacuo
4. customto give a viscous oil
5. stirringThe reaction mixture was stirred for three hours at room temperature
6. temperatureone hour at reflux
7. temperatureThe reaction mixture was then cooled to 0° C.
8. stirringThe suspension was then stirred at room temperature for two hours
9. filtrationwas filtered through a bed of Celite
10. concentrationThe filtrate was concentrated in vacuo

ORD record

ord-5c6019f9a30c476f905a37346c6bac6f

Source dataset

uspto-grants-1995_02

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US05389687