反应详情

温度

60 °C

A mixture of 3,4-dihydroxybenzaldehyde (5.0 g), benzyl bromide (14.8 g), potassium carbonate (13 g) and N,N-dimethylformamide (120 ml) was stirred for two hours at 60° C. To the reaction mixture was added cold water (200 ml), which was subjected to extraction with ethyl acetate (150 ml). The organic layer was washed with a 5% aqueous solution of potassium hydrogencarbonate, which was washed with water and dried over anhydrous sodium sulfate. The solvent was distilled off to leave 3,4-dibenzyloxybenzaldehyde (10.5 g) as colorless crystals. m.p.: 87-88° C.

1. extractionwas subjected to extraction with ethyl acetate (150 ml)
2. washThe organic layer was washed with a 5% aqueous solution of potassium hydrogencarbonate, which
3. washwas washed with water
4. dry with materialdried over anhydrous sodium sulfate
5. distillationThe solvent was distilled off