Piperidine → HCID 18315758, compound

HRID 275925Notes

Reaction equation

HRID 275925 reaction equation
[NH:1]1[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[Cl:14][C:15]1[N:20]=[C:19]([N:21]2[CH2:30][CH2:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]2[CH3:31])[C:18]([CH3:32])=[C:17]([CH3:33])[N:16]=1>CN(C)C=O>[ClH:14].[CH3:32][C:18]1[C:19]([N:21]2[CH2:30][CH2:29][C:28]3[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=3)[CH:22]2[CH3:31])=[N:20][C:15]([N:1]2[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]2)=[N:16][C:17]=1[CH3:33]

Participants

5

Reactant 3

HCID 8082PiperidineHCID 8471TriethylamineHCID 111853185,6-Dimethyl-2-chloro4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine

Product 1

HCID 18315758HCID 18315758, compoundYield 75.5%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After piperidine(0.26 ml, 2.61 mmol) and triethylamine(0.36 ml, 2.59 mmol) were added to a solution of 2-chloro-5,6-dimethyl-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine(0.5 g, 1.74 mmol) in dimethylformamide, 490 mg of the titled compound was obtained in accordance with the same procedure as in Example 1.

Sources & evidence

ORD record
ord-d26e7fc113b0446c8c06972307b93ce6
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Reaction notes

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