Triethylamine → HCID 18315658, compound

HRID 275948Notes

Reaction equation

HRID 275948 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]([O:13][CH3:14])=[C:9]2[C:4]=1[CH2:5][CH2:6][NH:7][CH:8]2[CH3:15].C(N(CC)CC)C.[CH3:23][C:24]1[C:25](Cl)=[N:26][C:27]([Cl:31])=[N:28][C:29]=1[CH3:30]>CN(C)C=O>[CH3:23][C:24]1[C:25]([N:7]2[CH2:6][CH2:5][C:4]3[C:9](=[C:10]([O:13][CH3:14])[CH:11]=[CH:12][C:3]=3[O:2][CH3:1])[CH:8]2[CH3:15])=[N:26][C:27]([Cl:31])=[N:28][C:29]=1[CH3:30]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 2415532,4-Dichloro-5,6-dimethylpyrimidineHCID 18315710HCID 18315710, compound

Product 1

HCID 18315658HCID 18315658, compoundYield 72.9%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 5,8-dimethoxy-1-methyl-1,2,3,4-tetrahydroisoquinoline(10 g, 4.82 mmol) and triethylamine (0.67 ml, 4.82 mmol) were added to a suspension of 5,6-dimethyl-2,4-dichloropyrimidine(0.71 g, 4.02 mmol) in dimethylformamide, 1.02 g of the titled compound was obtained in accordance with the same procedure as in Step 1 of Example 35. (Yield: 72.8%)

Sources & evidence

ORD record
ord-34f82632a800436688aa009e0b5e3aba
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Reaction notes

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