Triethylamine → HCID 18315771, compound

HRID 275949Notes

Reaction equation

HRID 275949 reaction equation
[F:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][CH:3]=1.C(N(CC)CC)C.[CH3:16][C:17]1[C:18]([N:25]2[CH2:34][CH2:33][C:32]3[C:27](=[C:28]([O:37][CH3:38])[CH:29]=[CH:30][C:31]=3[O:35][CH3:36])[CH:26]2[CH3:39])=[N:19][C:20]([Cl:24])=[N:21][C:22]=1[CH3:23]>CN(C)C=O>[ClH:24].[CH3:16][C:17]1[C:18]([N:25]2[CH2:34][CH2:33][C:32]3[C:27](=[C:28]([O:37][CH3:38])[CH:29]=[CH:30][C:31]=3[O:35][CH3:36])[CH:26]2[CH3:39])=[N:19][C:20]([NH:6][C:5]2[CH:7]=[CH:8][C:2]([F:1])=[CH:3][CH:4]=2)=[N:21][C:22]=1[CH3:23]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 97314-FluoroanilineHCID 18315658HCID 18315658, compound

Product 1

HCID 18315771HCID 18315771, compoundYield 51.2%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

After 4-fluoroaniline(0.40 ml, 4.13 mmol) and triethylamine(0.58 ml, 4.13 mmol) were added to a solution of 5,6-dimethyl-2-chloro-4-(5,8-dimethoxy-1-methyl-1,2,3,4tetrahydroisoquinolin-2-yl)pyrimidine (1.0 g, 2.87 mmol) in dimethylformamide(5 ml), 0.67 g of the titled compound was obtained in accordance with the same procedure as in Step 2 of Example 25. (Yield: 51.2%)

Sources & evidence

ORD record
ord-f54dab7210604292a3ab471ac4c236d7
Source dataset
uspto-grants-2002_03
Patent number
US06352993B1

Reaction notes

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