反应详情

温度

60 °C

A solution containing 1.10 g of N-1-butanesulfonyl-3-amino-4-nitrobenzamide, 0.273 g of sodium iodide, 1.54 g of potassium carbonate, 2.17 g of 2,4-dichlorobenzyl chloride and 10 ml of methanol was stirred at 60° C. for 24 hours. Further, 2.00 g of 2,4-dichlorobenzyl chloride were added thereto, and the mixture was heated at 60° C. for 36 hours. To the reaction solution were added ethyl acetate and a saturated aqueous solution of sodium hydrogencarbonate, and N-1-butanesulfonyl-3-(2,4-dichlorobenzylamino)-4-nitrobenzamide was extracted in the aqueous layer. The organic layer was concentrated to give 0.885 g of N-1-butanesulfonyl-3-(2,4-dichlorobenzylamino)-4-nitrobenzamide.

1. temperaturethe mixture was heated at 60° C. for 36 hours
2. extractiona saturated aqueous solution of sodium hydrogencarbonate, and N-1-butanesulfonyl-3-(2,4-dichlorobenzylamino)-4-nitrobenzamide was extracted in the aqueous layer
3. concentrationThe organic layer was concentrated