Hydrochloric Acid → 4-[(1-H-Benzimidazol-2-ylamino)-methyl]-piperidine bis-hydrochloride

HRID 277887Notes

Reaction equation

HRID 277887 reaction equation
[ClH:1].C([N:9]1[CH2:14][CH2:13][CH:12]([CH2:15][NH:16][C:17]2[NH:21][C:20]3[CH:22]=[CH:23][CH:24]=[CH:25][C:19]=3[N:18]=2)[CH2:11][CH2:10]1)(OC(C)(C)C)=O>CCOC(C)=O>[ClH:1].[ClH:1].[NH:18]1[C:19]2[CH:25]=[CH:24][CH:23]=[CH:22][C:20]=2[N:21]=[C:17]1[NH:16][CH2:15][CH:12]1[CH2:13][CH2:14][NH:9][CH2:10][CH2:11]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21912578tert-butyl 4-[(1H-benzimidazol-2-ylamino)methyl]piperidine-1-carboxylate

Product 1

HCID 867578694-[(1-H-Benzimidazol-2-ylamino)-methyl]-piperidine bis-hydrochloride

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Conditions

Temperature
0 °C

Procedure

HCl gas was passed through a solution of 5-2 (1.3 g, 3.9 mmol) in EtOAc (25 mL) at 0° C. for 3 min. After stirring at 0° C. for an additional 2 hrs, the reaction mixture was concentrated to give 5-3 as a solid.

Workup

  1. concentrationthe reaction mixture was concentrated

Sources & evidence

ORD record
ord-ce9e4592ccd64aa789bb3733319b718d
Source dataset
uspto-grants-2002_03
Patent number
US06358970B1

Reaction notes

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