1,1'-Carbonyldiimidazole → HCID 86757870, compound

HRID 277899Notes

Reaction equation

HRID 277899 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:12])[C:7]=1CC(O)=O.C(N1C=CN=C1)(N1C=CN=C1)=[O:14].[CH:25]1([CH2:30][CH:31]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=2)[CH2:32][NH2:33])[CH2:29][CH2:28][CH2:27]C1>C1COCC1>[CH2:29]1[CH2:28][CH2:27][CH:30]([C:31]([C:34]2[CH:39]=[CH:38][CH:37]=[C:36]([O:40][CH3:41])[CH:35]=2)([C:7]2[C:6]([Cl:12])=[CH:5][N:4]=[CH:3][C:2]=2[Cl:1])[C:32]([NH2:33])=[O:14])[CH2:25]1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 22626827HCID 22626827, compoundHCID 226268513-Cyclopentyl-2-(3-methoxy-phenyl)-propylamine

Product 1

HCID 86757870HCID 86757870, compoundYield 98.3%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By working in a way similar to that described in example 4 but using (3,5-dichloro-pyridin-4-yl)-acetic acid (1.94 g, 9.43 mmoles), carbonyldiimidazole (1.68 g, 10.373 mmoles), THF (30 ml) and 3-cyclopentyl-2-(3-methoxy-phenyl)-propylamine (2.2 g, 9.43 mmoles), obtained as described in example 8, 3.35 g of the title compound were obtained (yield: 98.3%), m.p.: 106-107° C.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-94b7c831945a439ea577e74e2411a335
Source dataset
uspto-grants-2002_03
Patent number
US06358973B1

Reaction notes

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