1,1'-Carbonyldiimidazole → HCID 22626826, compound

HRID 277902Notes

Reaction equation

HRID 277902 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:12])[C:7]=1[CH2:8][C:9]([OH:11])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:33]([CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][C:42]2[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=2)[CH2:34][NH2:35])[CH:30]=[CH:31][CH:32]=1>C1COCC1>[Cl:12][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[CH2:8][C:9]([NH:35][CH2:34][CH:33]([C:29]1[CH:30]=[CH:31][CH:32]=[C:27]([O:26][CH3:25])[CH:28]=1)[CH2:36][CH2:37][CH2:38][CH2:39][CH2:40][CH2:41][C:42]1[CH:47]=[CH:46][CH:45]=[CH:44][CH:43]=1)=[O:11]

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 22626827HCID 22626827, compoundHCID 22626852HCID 22626852, compound

Product 1

HCID 22626826HCID 22626826, compoundYield 84.6%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By working in a way similar to that described in example 4 but using (3,5-dichloro-pyridin-4-yl)-acetic acid (1.65 g, 8.026 mmoles), carbonyldiimidazole (1.43 g, 8.829 mmoles), THF (25 ml) and 2-(3-methoxy-phenyl)-8-phenyl-octylamine (2.5 g, 8.026 mmoles), obtained as described in example 13, 3.39 g of the title compound were obtained (yield: 84.6%), m.p.: 97-98° C.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-d23245bb462343c4bc1ed561d00ed4a4
Source dataset
uspto-grants-2002_03
Patent number
US06358973B1

Reaction notes

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