1,1'-Carbonyldiimidazole → HCID 22626839, compound

HRID 277913Notes

Reaction equation

HRID 277913 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:12])[C:7]=1[CH2:8][C:9]([OH:11])=O.C(N1C=CN=C1)([N:15]1C=CN=C1)=O.[CH:25]1([CH:30]([C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([O:39][CH3:40])[CH:34]=2)CN)[CH2:29][CH2:28][CH2:27][CH2:26]1>C1COCC1>[CH:25]1([CH:30]([C:33]2[CH:38]=[CH:37][CH:36]=[C:35]([O:39][CH3:40])[CH:34]=2)[NH:15][C:9](=[O:11])[CH2:8][C:7]2[C:6]([Cl:12])=[CH:5][N:4]=[CH:3][C:2]=2[Cl:1])[CH2:29][CH2:28][CH2:27][CH2:26]1

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 22626824HCID 22626824, compoundHCID 22626827HCID 22626827, compound

Product 1

HCID 22626839HCID 22626839, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By working in a way similar to that described in example 30 but using (3,5-dichloro-pyridin-4-yl)-acetic acid (2.06 g, 10 mmoles), carbonyldiimidazole (1.78 g, 11 mmoles), THF (30 ml) and 2-cyclopentyl-2-(3-methoxy-phenyl)-ethylamine (2.19 g, 10 mmoles), obtained as described in example 33, 3.8 g of the title compound were obtained (yield: 98.2%), m.p.: 105-106° C.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-403b6db1d788429198efa20948520b3a
Source dataset
uspto-grants-2002_03
Patent number
US06358973B1

Reaction notes

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