1,1'-Carbonyldiimidazole → HCID 22626830, compound

HRID 277917Notes

Reaction equation

HRID 277917 reaction equation
[Cl:1][C:2]1[CH:3]=[N:4][CH:5]=[C:6]([Cl:12])[C:7]=1[CH2:8][C:9]([OH:11])=O.C(N1C=CN=C1)(N1C=CN=C1)=O.[CH3:25][O:26][C:27]1[CH:28]=[C:29]([CH:33]([C:36]2[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=2)[CH2:34][NH2:35])[CH:30]=[CH:31][CH:32]=1>C1COCC1>[Cl:12][C:6]1[CH:5]=[N:4][CH:3]=[C:2]([Cl:1])[C:7]=1[CH2:8][C:9]([NH:35][CH2:34][CH:33]([C:29]1[CH:30]=[CH:31][CH:32]=[C:27]([O:26][CH3:25])[CH:28]=1)[C:36]1[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=1)=[O:11]

Participants

5

Reactant 3

HCID 682631,1'-CarbonyldiimidazoleHCID 22626827HCID 22626827, compoundHCID 22626836HCID 22626836, compound

Product 1

HCID 22626830HCID 22626830, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

By working in a way similar to that described in example 4 but using (3.5-dichloro-pyridin-4-yl)-acetic acid (5.15 g, 25 mmoles), carbonyldiimidazole (4.24 g, 26.14 mmoles), THF (75 ml) and 2-(3-methoxy-phenyl)-2-phenyl-ethylamine (5.4 g, 23.76 mmoles), obtained as described in example 42, 8.9 g of the title compound were obtained (yield: 85.7%), m.p.: 142-143° C.

Workup

  1. customobtained

Sources & evidence

ORD record
ord-89c88b20cdb6485fa4b9fbe91bdd1387
Source dataset
uspto-grants-2002_03
Patent number
US06358973B1

Reaction notes

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