Sodium Thiosulfate → 4,5-Dimethyl-2-Methylsulphonyloxazole

HRID 277974Notes

Reaction equation

HRID 277974 reaction equation
CS[C:3]1[O:4][C:5]([CH3:9])=[C:6]([CH3:8])[N:7]=1.[CH:10]1C=C(Cl)C=C(C(OO)=O)C=1.[S:21]([O-:25])([O-])(=[O:23])=S.[Na+].[Na+].C(=O)([O-])O.[Na+]>C(Cl)Cl>[CH3:10][S:21]([C:3]1[O:4][C:5]([CH3:9])=[C:6]([CH3:8])[N:7]=1)(=[O:25])=[O:23]

Participants

6

Reactant 4

HCID 24477Sodium ThiosulfateHCID 70297m-Chloroperbenzoic acidHCID 516892Sodium BicarbonateHCID 112520762-Methylthio-4,5-dimethyloxazole

Product 1

HCID 226270084,5-Dimethyl-2-Methylsulphonyloxazole

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3 g of 2-methylthio-4,5-dimethyloxazole were dissolved in 100 ml of methylene chloride and 13 g of mCPBA were added at ice temperature. The batch was stirred for three hours and then added to sodium thiosulfate solution. It was neutralized with sodium hydrogencarbonate and the product was extracted with methylene chloride. After drying over magnesium sulfate, the solvent was distilled off and 2 g of crude product were isolated, which it was directly possible to employ further.

Workup

  1. extractionthe product was extracted with methylene chloride
  2. dry with materialAfter drying over magnesium sulfate
  3. distillationthe solvent was distilled off

Sources & evidence

ORD record
ord-52ebc5786193449d96e4f8881fef9947
Source dataset
uspto-grants-2002_03
Patent number
US06358983B1

Reaction notes

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