反应详情

温度

100 °C

A mixture of ethyl 4-fluorobenzoate (8.4 g), 1,2,4-triazole (4.14 g) and potassium carbonate (20.7 g) in DMF (30 ml) was stirred at 100° C. for 3 hours and concentrated. To the residue was added dichloromethane, and the mixture was washed with water, dried and concentrated. The residue was purified with silica gel column chromatography (dichloromethane:methanol=50:1→20:1) to give a colorless solid of ethyl 4-(1,2,4-triazol-1-yl)benzoate (4.0 g) and ethyl 4-(1,2,4- triazol-4- yl)benzoate (369 mg).

1. concentrationconcentrated
2. additionTo the residue was added dichloromethane
3. washthe mixture was washed with water
4. customdried
5. concentrationconcentrated
6. customThe residue was purified with silica gel column chromatography (dichloromethane:methanol=50:1→20:1)