Hydrochloric Acid → 1-[2-(4-Chlorophenyl)ethynesulfonyl]piperazine hydrochloride

HRID 278579Notes

Reaction equation

HRID 278579 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][N:11]([S:14]([C:17]#[C:18][C:19]2[CH:24]=[CH:23][C:22]([Cl:25])=[CH:21][CH:20]=2)(=[O:16])=[O:15])[CH2:10][CH2:9]1)=O)(C)(C)C.Cl>C(OCC)(=O)C>[ClH:25].[Cl:25][C:22]1[CH:23]=[CH:24][C:19]([C:18]#[C:17][S:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)(=[O:16])=[O:15])=[CH:20][CH:21]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 226280621-(Tert-butoxycarbonyl)-4-[2-(4-chlorophenyl)ethynesulfonyl]piperazine

Product 1

HCID 226280021-[2-(4-Chlorophenyl)ethynesulfonyl]piperazine hydrochlorideYield 182.1%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1-(tert-Butoxycarbonyl)-4-[2-(4-chlorophenyl)ethynesulfonyl]piperazine (500 mg) was treated with 4N hydrochloric acid in ethyl acetate to give a colorless solid of the title compound (380 mg).

Sources & evidence

ORD record
ord-0ea6e2abc8d243388cf9f0006b4d0563
Source dataset
uspto-grants-2002_03
Patent number
US06359134B1

Reaction notes

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