Hydrochloric Acid → HCID 18628934, compound

HRID 278603Notes

Reaction equation

HRID 278603 reaction equation
C(OC([NH:8][C:9]([C:11]1[CH:38]=[CH:37][C:14]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([S:23]([C:26]3[CH:35]=[CH:34][C:33]4[C:28](=[CH:29][CH:30]=[C:31]([Cl:36])[CH:32]=4)[CH:27]=3)(=[O:25])=[O:24])[CH2:19][CH2:18]2)=[O:16])=[CH:13][CH:12]=1)=[NH:10])=O)(C)(C)C.Cl.CCOCC>C(OCC)(=O)C>[ClH:36].[C:9]([C:11]1[CH:12]=[CH:13][C:14]([C:15]([N:17]2[CH2:18][CH2:19][N:20]([S:23]([C:26]3[CH:35]=[CH:34][C:33]4[C:28](=[CH:29][CH:30]=[C:31]([Cl:36])[CH:32]=4)[CH:27]=3)(=[O:24])=[O:25])[CH2:21][CH2:22]2)=[O:16])=[CH:37][CH:38]=1)(=[NH:8])[NH2:10]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 145840730HCID 145840730, compound

Product 1

HCID 18628934HCID 18628934, compoundYield 153.5%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 1-(4-tert-butoxycarbonylamidino benzoyl)-4-(6-chloronaphthalene-2-sulfonyl)piperazine (150 mg) was added 4 N hydrochloric acid in ethyl acetate solution (15 ml) and the solution was allowed to stand at room temperature for 5 hours, to which was added ether. The precipitate was filtered, washed with ether and dried to give a colorless solid of the title compound (102 mg).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-3ac7963cdaac43489866917649e8b98f
Source dataset
uspto-grants-2002_03
Patent number
US06359134B1

Reaction notes

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