Hydrochloric Acid → HCID 178479380, compound

HRID 278604Notes

Reaction equation

HRID 278604 reaction equation
C(OC([N:8]=[C:9]([NH:39]C(OC(C)(C)C)=O)[NH:10][C:11]1[CH:38]=[CH:37][C:14]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([S:23]([C:26]3[CH:35]=[CH:34][C:33]4[C:28](=[CH:29][CH:30]=[C:31]([Cl:36])[CH:32]=4)[CH:27]=3)(=[O:25])=[O:24])[CH2:19][CH2:18]2)=[O:16])=[CH:13][CH:12]=1)=O)(C)(C)C.Cl.CCOCC>C(OCC)(=O)C>[ClH:36].[NH:10]([C:11]1[CH:12]=[CH:13][C:14]([C:15]([N:17]2[CH2:22][CH2:21][N:20]([S:23]([C:26]3[CH:35]=[CH:34][C:33]4[C:28](=[CH:29][CH:30]=[C:31]([Cl:36])[CH:32]=4)[CH:27]=3)(=[O:24])=[O:25])[CH2:19][CH2:18]2)=[O:16])=[CH:37][CH:38]=1)[C:9]([NH2:39])=[NH:8]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 178454284HCID 178454284, compound

Product 1

HCID 178479380HCID 178479380, compoundYield 171.2%

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To 1-[4-(2,3-di-tert-butoxycarbonylguanidino)benzoyl]-4-(6-chloronaphthalene-2-sulfonyl)piperazine (295 mg) was added 4 N hydrochloric acid in ethyl acetate solution (20 ml) and the solution was allowed to stand at room temperature for 3 hours, to which was added ether. The precipitate was filtered, washed with ether and dried to give a colorless solid of the title compound (191 mg).

Workup

  1. filtrationThe precipitate was filtered
  2. washwashed with ether
  3. customdried

Sources & evidence

ORD record
ord-6ee70dde4d7240448b4c33d877ee0f15
Source dataset
uspto-grants-2002_03
Patent number
US06359134B1

Reaction notes

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