反应详情

To a stirred solution of 6.8 g. of phenylurea in 50 ml. of dry THF maintained at 0° C. under nitrogen were added 5.05 g. of p-nitrophenyl chloroformate. The reaction mixture was allowed to warm to room temperture and was stirred for about 18 hours. The mixture was evaporated to dryness and the residue dissolved in ethyl acetate. The solution was washed twice with water, twice with brine, and was filtered through sodium sulfate. The filtrate was evaporated to dryness to yield 4.9 g. of the product as a white product.

1. additionwere added 5.05 g
2. temperatureto warm to room temperture
3. customThe mixture was evaporated to dryness
4. dissolutionthe residue dissolved in ethyl acetate
5. washThe solution was washed twice with water, twice with brine
6. filtrationwas filtered through sodium sulfate
7. customThe filtrate was evaporated to dryness
8. customto yield 4.9 g