反应详情

A stirred mixture of p-anisaldehyde (60.7 ml), ammonium acetate (7.5 g), cyanoacetic acid (42.5 g), pyridone (70 ml) in toluene (390 ml) is refluxed using a Dean Stark trap until about 9 ml of water is collected. The reaction mixture is cooled and the solid precipitate filtered and stirred with 10% aqueous HCL. The solid is filtered and recrystallized from methanol yielding the desired product.

1. temperatureis refluxed
2. customis collected
3. temperatureThe reaction mixture is cooled
4. filtrationthe solid precipitate filtered
5. filtrationThe solid is filtered
6. customrecrystallized from methanol yielding the desired product