反应详情

温度

0 °C

Triethylamine (10 ml) is added to a stirred solution of the 1-hydroxy indane of Step 2. above (8.4 g) in methylene chloride (190 ml) at RT under nitrogen; the mixture is cooled to 0° C. and methanesulfonyl chloride (4 ml) is added. The mixture is stirred for three hours at RT, cooled to 0° C., piperidine (128 ml) added and stirred at RT overnight. Sat'd aq. sodium bicarbonate is added to the mixture and the organic phase separated, washed with aq. sodium bicarbonate, sat'd NaCl, dried, filtered and the filtrate evaporated in vacuo affording the desired product as an oil.

1. customat RT
2. temperaturecooled to 0° C.
3. stirringstirred at RT overnight
4. customthe organic phase separated
5. washwashed with aq. sodium bicarbonate
6. customdried
7. filtrationfiltered
8. customthe filtrate evaporated in vacuo