Acetonitrile → N-methyl-4-(thiophen-2-yl)-5-(2-(trimethylsilyl)ethynyl)pyrimidin-2-amine

HRID 282971Notes

Reaction equation

[Br:1][c:2]1[c:3](-[c:10]2[s:11][cH:12][cH:13][cH:14]2)[n:4][c:5]([NH:8][CH3:9])[n:6][cH:7]1.[C:22](#[CH:23])[Si:24]([CH3:25])([CH3:26])[CH3:27].[CH3:15][CH2:16][N:17]([CH2:18][CH3:19])[CH2:20][CH3:21].[CH3:30][C:31]#[N:32].[Cu:28][I:29]>>[c:2]1([C:23]#[C:22][Si:24]([CH3:25])([CH3:26])[CH3:27])[c:3](-[c:10]2[s:11][cH:12][cH:13][cH:14]2)[n:4][c:5]([NH:8][CH3:9])[n:6][cH:7]1

Participants

Reactant 5

HCID 6342Acetonitrile

HCID 8471Triethylamine

HCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)

HCID 66111Trimethylsilylacetylene

HCID 684594085-bromo-N-methyl-4-(thiophen-2-yl)pyrimidin-2-amine

Product 1

HCID 68459491N-methyl-4-(thiophen-2-yl)-5-(2-(trimethylsilyl)ethynyl)pyrimidin-2-amine

Sources & evidence

ORD record: ord-ed1cec84db684392916d74b22078d3fc
Source dataset: Training data from https://doi.org/10.1039/C8SC04228D (8/10)
DOI: 10.1039/C8SC04228D

Reaction notes

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