Triethylamine → 2-Fluoro-5-(5-methoxypyridin-3-ylethynyl)-benzoic acid

HRID 283213Notes

Reaction equation

HRID 283213 reaction equation
[C:1](#[CH:2])[c:3]1[cH:4][n:5][cH:6][c:7]([O:9][CH3:10])[cH:8]1.[CH3:22][CH2:23][N:24]([CH2:25][CH3:26])[CH2:27][CH3:28].[Cu:70][I:71].[F:11][c:12]1[c:13]([C:14](=[O:15])[OH:16])[cH:17][c:18]([I:21])[cH:19][cH:20]1.[Pd:29]([Cl:30])[Cl:31].[c:32]1([P:33]([c:34]2[cH:35][cH:36][cH:37][cH:38][cH:39]2)[c:40]2[cH:41][cH:42][cH:43][cH:44][cH:45]2)[cH:46][cH:47][cH:48][cH:49][cH:50]1.[c:51]1([P:52]([c:53]2[cH:54][cH:55][cH:56][cH:57][cH:58]2)[c:59]2[cH:60][cH:61][cH:62][cH:63][cH:64]2)[cH:65][cH:66][cH:67][cH:68][cH:69]1>>[C:1](#[C:2][c:18]1[cH:17][c:13]([C:14](=[O:15])[OH:16])[c:12]([F:11])[cH:20][cH:19]1)[c:3]1[cH:4][n:5][cH:6][c:7]([O:9][CH3:10])[cH:8]1

Participants

7

Reactant 6

HCID 8471TriethylamineHCID 11776Triphenylphosphine2×HCID 24290Palladium ChlorideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 27789252-Fluoro-5-iodobenzoic acidHCID 210973493-Ethynyl-5-methoxypyridine

Product 1

HCID 670477592-Fluoro-5-(5-methoxypyridin-3-ylethynyl)-benzoic acid

Sources & evidence

ORD record
ord-d0a6cabe6e4d4e2d924048c77f6fc8bf
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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