反应详情

A mixture of 2.0 g (0.0008 mol) of trans-ethyl 4-(4-aminocyclohexyl)benzoate, 1.25 ml of triethylamine and 1.26 ml (0.0084 mol) of benzyl chloroformate at 95% in 40 ml of dimethylformamide is stirred at room temperature for 3 hours. The mixture is poured into water, extracted with ethyl acetate and dried, and the solvent is evaporated off. The residue is purified by chromatography on a silica gel column, eluting with an 8/2 cyclohexane/ethyl acetate mixture. The compound of the title is obtained.

1. extractionextracted with ethyl acetate
2. customdried
3. customthe solvent is evaporated off
4. customThe residue is purified by chromatography on a silica gel column
5. washeluting with an 8/2 cyclohexane/ethyl acetate mixture
6. customThe compound of the title is obtained