Tetrahydrofuran → (Z)-N-(5-tert-butyl-3-((1-hydroxycyclohexyl)methyl)thiazol-2(3H)-ylidene)-5-chloro-2-methoxybenzamide

HRID 284288Notes

Reaction equation

HRID 284288 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][n:7]([CH2:11][C:12]2([OH:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)[c:8](=[NH:10])[s:9]1.[CH2:42]1[O:43][CH2:44][CH2:45][CH2:46]1.[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[Cl:19][c:20]1[cH:21][cH:22][c:23]([O:29][CH3:30])[c:24]([C:25](=[O:26])[OH:27])[cH:28]1.[S:31]([Cl:32])([Cl:33])=[O:34]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[c:5]1[cH:6][n:7]([CH2:11][C:12]2([OH:18])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17]2)[c:8](=[N:10][C:25]([c:24]2[c:23]([O:29][CH3:30])[cH:22][cH:21][c:20]([Cl:19])[cH:28]2)=[O:26])[s:9]1

Participants

6

Reactant 5

HCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 24386Thionyl ChlorideHCID 769705-Chloro-o-anisic acidHCID 668518251-((5-tert-butyl-2-iminothiazol-3(2H)-yl)methyl)cyclohexanol

Product 1

HCID 66851559(Z)-N-(5-tert-butyl-3-((1-hydroxycyclohexyl)methyl)thiazol-2(3H)-ylidene)-5-chloro-2-methoxybenzamide

Sources & evidence

ORD record
ord-fb3b9d87a96748d4854f477b4703cece
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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