Potassium Cation → (2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-cyclohexyl-1H-benzo[d]imidazol-5-yl)methanol

HRID 284654Notes

Reaction equation

HRID 284654 reaction equation
[Br:1][c:2]1[cH:3][c:4]2[c:5]([I:19])[n:6][n:7]([CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:16])([CH3:17])[CH3:18])[c:8]2[cH:9][cH:10]1.[CH3:38][NH:39][CH:40]1[CH2:41][CH2:42][CH2:43][CH2:44][CH:45]1[NH:46][CH3:47].[CH3:61][CH2:62][O:63][C:64](=[O:65])[CH3:66].[Cu:67][I:68].[K+:53].[K+:54].[K+:55].[NH2:20][c:21]1[n:22][c:23]2[c:24]([n:25]1[CH:26]1[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]1)[cH:32][cH:33][c:34]([CH2:36][OH:37])[cH:35]2.[O:56]1[CH2:57][CH2:58][CH2:59][CH2:60]1.[P:48]([O-:49])([O-:50])([O-:51])=[O:52]>>[Br:1][c:2]1[cH:3][c:4]2[c:5]([NH:20][c:21]3[n:22][c:23]4[c:24]([n:25]3[CH:26]3[CH2:27][CH2:28][CH2:29][CH2:30][CH2:31]3)[cH:32][cH:33][c:34]([CH2:36][OH:37])[cH:35]4)[n:6][n:7]([CH2:11][O:12][CH2:13][CH2:14][Si:15]([CH3:16])([CH3:17])[CH3:18])[c:8]2[cH:9][cH:10]1

Participants

9

Reactant 8

HCID 813Potassium Cation3×HCID 1061PhosphateHCID 8028TetrahydrofuranHCID 8857Ethyl AcetateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 5510741-N,2-N-dimethylcyclohexane-1,2-diamineHCID 583172565-Bromo-3-iodo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazoleHCID 67252967(2-Amino-1-cyclohexyl-1H-benzimidazol-5-yl)methanol

Product 1

HCID 67255070(2-(5-bromo-1-((2-(trimethylsilyl)ethoxy)methyl)-1H-indazol-3-ylamino)-1-cyclohexyl-1H-benzo[d]imidazol-5-yl)methanol

Sources & evidence

ORD record
ord-adde03c1360f4cc893ed013bdc01318f
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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