Ammonia → 9-(4-{[(5-Cyanopyridin-2-yl)oxy]methyl}-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide

HRID 285095Notes

Reaction equation

HRID 285095 reaction equation
[C:13](#[N:14])[c:15]1[cH:16][cH:17][c:18]([O:21][CH2:22][CH:23]2[C:24]([CH3:41])([CH3:42])[C:25](=[O:40])[N:26]([CH:28]3[CH:29]4[CH2:30][CH:31]([C:37](=[O:38])[OH:39])[CH2:32][CH:33]3[CH2:34][CH2:35][CH2:36]4)[CH2:27]2)[n:19][cH:20]1.[CH2:2]([N:4]=[C:3]=[N:5][CH2:6][CH2:7][CH2:8][N:9]([CH3:10])[CH3:11])[CH3:12].[CH:54]([N:55]([CH:56]([CH3:57])[CH3:58])[CH2:59][CH3:60])([CH3:61])[CH3:62].[Cl:64][CH2:65][Cl:66].[ClH:1].[NH3:63].[OH2:43].[OH:44][n:45]1[c:46]2[cH:47][cH:48][cH:49][cH:50][c:51]2[n:52][n:53]1>>[NH2:4][C:37]([CH:31]1[CH2:30][CH:29]2[CH:28]([N:26]3[C:25](=[O:40])[C:24]([CH3:41])([CH3:42])[CH:23]([CH2:22][O:21][c:18]4[cH:17][cH:16][c:15]([C:13]#[N:14])[cH:20][n:19]4)[CH2:27]3)[CH:33]([CH2:32]1)[CH2:34][CH2:35][CH2:36]2)=[O:39]

Participants

9

Reactant 8

HCID 222AmmoniaHCID 313Hydrochloric AcidHCID 962WaterHCID 6344DichloromethaneHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 757711-HydroxybenzotriazoleHCID 81531DiisopropylethylamineHCID 666569469-[4-(5-Cyano-pyridin-2-yloxymethyl)-3,3-dimethyl-2-oxo-pyrrolidin-1-yl]-bicyclo[3.3.1]nonane-3-carboxylic acid

Product 1

HCID 248899069-(4-{[(5-Cyanopyridin-2-yl)oxy]methyl}-3,3-dimethyl-2-oxopyrrolidin-1-yl)bicyclo[3.3.1]nonane-3-carboxamide

Sources & evidence

ORD record
ord-9e47bb85fae34e9c9854c781b32eb3ea
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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