Tetrahydrofuran → N-{4-[6-Cyano-7-(2-hydroxy-3-(pyrrolidin-1-yl)propoxy)quinolin-4-yloxy]-2-fluorophenyl)-N'-(thiazol-2-yl)urea
Reaction equation
[C:6](#[N:7])[c:8]1[cH:9][c:10]2[c:11]([O:23][c:24]3[cH:25][c:26]([F:39])[c:27]([NH:30][C:31](=[O:32])[NH:33][c:34]4[s:35][cH:36][cH:37][n:38]4)[cH:28][cH:29]3)[cH:12][cH:13][n:14][c:15]2[cH:16][c:17]1[O:18][CH2:19][CH:20]1[O:21][CH2:22]1.[CH2:1]1[CH2:2][CH2:3][NH:4][CH2:5]1.[O:40]1[CH2:41][CH2:42][CH2:43][CH2:44]1>>[CH2:1]1[CH2:2][CH2:3][N:4]([CH2:22][CH:20]([CH2:19][O:18][c:17]2[c:8]([C:6]#[N:7])[cH:9][c:10]3[c:11]([O:23][c:24]4[cH:25][c:26]([F:39])[c:27]([NH:30][C:31](=[O:32])[NH:33][c:34]5[s:35][cH:36][cH:37][n:38]5)[cH:28][cH:29]4)[cH:12][cH:13][n:14][c:15]3[cH:16]2)[OH:21])[CH2:5]1Participants
4
Sources & evidence
- ORD record
- ord-0ffcde62bfa3408caa5eb9a52d17c8ba
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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