Chloride → 4-hydroxy-3,3-dimethyl-4-[5-triisopropylsilanyl-2-(3,4,5-trimethoxy-phenyl)-5H-pyrrolo[2,3-b]pyrazin-7-yl]-butyronitrile
Reaction equation
[CH2:4]([Mg+:5])[CH2:6][CH3:7].[CH3:40][C:41]([CH2:42][C:43]#[N:44])([CH:45]=[O:46])[CH3:47].[Cl-:1].[Cl-:3].[I:8][c:9]1[cH:10][n:11]([Si:30]([CH:31]([CH3:32])[CH3:33])([CH:34]([CH3:35])[CH3:36])[CH:37]([CH3:38])[CH3:39])[c:12]2[n:13][cH:14][c:15](-[c:18]3[cH:19][c:20]([O:28][CH3:29])[c:21]([O:26][CH3:27])[c:22]([O:24][CH3:25])[cH:23]3)[n:16][c:17]12.[Li+:2].[O:48]1[CH2:49][CH2:50][CH2:51][CH2:52]1>>[c:9]1([CH:45]([C:41]([CH3:40])([CH2:42][C:43]#[N:44])[CH3:47])[OH:46])[cH:10][n:11]([Si:30]([CH:31]([CH3:32])[CH3:33])([CH:34]([CH3:35])[CH3:36])[CH:37]([CH3:38])[CH3:39])[c:12]2[n:13][cH:14][c:15](-[c:18]3[cH:19][c:20]([O:28][CH3:29])[c:21]([O:26][CH3:27])[c:22]([O:24][CH3:25])[cH:23]3)[n:16][c:17]12Participants
7
Reactant 6
Product 1
Sources & evidence
- ORD record
- ord-3021bd246c824571974bc4748b4be25e
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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