Water → 6-chloro-4'-{5-chloro-2-[1-ethyl-1-(pyrrolidine-1-carbonyl)-propoxy]-phenyl}-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

HRID 286717Notes

Reaction equation

HRID 286717 reaction equation
[CH2:42]1[CH2:43][CH2:44][NH:45][CH2:46]1.[CH3:72][N:73]([c:74]1[cH:75][cH:76][n:77][cH:78][cH:79]1)[CH3:80].[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:34]2[c:35]([CH3:41])[cH:36][cH:37][c:38]([F:40])[cH:39]2)[NH:13][C:14](=[O:33])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH2:26][CH3:27])([C:28](=[O:29])[OH:30])[CH2:31][CH3:32])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1.[O:81]=[CH:82][N:83]([CH3:84])[CH3:85].[OH2:71].[P-:47]([F:48])([F:49])([F:50])([F:51])([F:52])[F:53].[n:54]1([O:55][C:56]([N:57]([CH3:58])[CH3:59])=[N+:60]([CH3:61])[CH3:62])[c:63]2[n:64][cH:65][cH:66][cH:67][c:68]2[n:69][n:70]1>>[Cl:1][c:2]1[cH:3][cH:4][c:5]2[c:9]([cH:10]1)[NH:8][C:7](=[O:11])[C:6]21[CH:12]([c:34]2[c:35]([CH3:41])[cH:36][cH:37][c:38]([F:40])[cH:39]2)[NH:13][C:14](=[O:33])[CH2:15][CH:16]1[c:17]1[c:18]([O:24][C:25]([CH2:26][CH3:27])([C:28](=[O:29])[N:45]2[CH2:44][CH2:43][CH2:42][CH2:46]2)[CH2:31][CH3:32])[cH:19][cH:20][c:21]([Cl:23])[cH:22]1

Participants

8

Reactant 7

HCID 962WaterHCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 142844-(Dimethylamino)pyridineHCID 31268PyrrolidineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 749285676-chloro-4'-[5-chloro-2-(1-ethyl-1-hydroxycarbonyl-propoxy)-phenyl]-2'-(5-fluoro-2-methyl-phenyl) spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Product 1

HCID 749286336-chloro-4'-{5-chloro-2-[1-ethyl-1-(pyrrolidine-1-carbonyl)-propoxy]-phenyl}-2'-(5-fluoro-2-methyl-phenyl)spiro[3H-indole-3,3'-piperidine]-2,6'(1H)-dione

Sources & evidence

ORD record
ord-34556ab322c746959c74bcf8b76d76fc
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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