Chloroform → 5-Aminopyrazine-2-carbonitrile

HRID 286719Notes

Reaction equation

HRID 286719 reaction equation
[Br:1][c:2]1[n:3][cH:4][c:5]([NH2:8])[n:6][cH:7]1.[CH3:34][N:35]([CH3:36])[CH:37]=[O:38].[CH:30]([Cl:31])([Cl:32])[Cl:33].[Cu:39][I:40].[K:27][C:28]#[N:29].[O:9]1[CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26]1.[cH:41]1[cH:42][cH:43][c:44]([P:45]([Pd:46]([P:47]([c:48]2[cH:49][cH:50][cH:51][cH:52][cH:53]2)([c:54]2[cH:55][cH:56][cH:57][cH:58][cH:59]2)[c:60]2[cH:61][cH:62][cH:63][cH:64][cH:65]2)([P:66]([c:67]2[cH:68][cH:69][cH:70][cH:71][cH:72]2)([c:73]2[cH:74][cH:75][cH:76][cH:77][cH:78]2)[c:79]2[cH:80][cH:81][cH:82][cH:83][cH:84]2)[P:85]([c:86]2[cH:87][cH:88][cH:89][cH:90][cH:91]2)([c:92]2[cH:93][cH:94][cH:95][cH:96][cH:97]2)[c:98]2[cH:99][cH:100][cH:101][cH:102][cH:103]2)([c:104]2[cH:105][cH:106][cH:107][cH:108][cH:109]2)[c:110]2[cH:111][cH:112][cH:113][cH:114][cH:115]2)[cH:116][cH:117]1>>[c:2]1([C:28]#[N:29])[n:3][cH:4][c:5]([NH2:8])[n:6][cH:7]1

Participants

8

Reactant 7

HCID 6212ChloroformHCID 6228DimethylformamideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 2855718-Crown-6HCID 5995392-Amino-5-bromopyrazineHCID 178420554HCID 178420554, compoundHCID 178511842HCID 178511842, compound

Product 1

HCID 139252945-Aminopyrazine-2-carbonitrile

Sources & evidence

ORD record
ord-e0aa50ef6ccd4237a02c1e9dd8e7e19e
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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