Dimethylformamide → N-[4-(4-amino-6-cyano-7-formylpyrrolo[2,1-f][1,2,4]triazin-5-yl)phenyl]-N'-[2-fluoro-5-(trifluoromethyl)phenyl]urea
Reaction equation
[CH2:45]1[O:46][CH2:47][CH2:48][CH2:49]1.[CH3:35][CH2:36][CH2:37][CH2:38][Li:39].[NH2:1][c:2]1[n:3][cH:4][n:5][n:6]2[c:7]1[c:8](-[c:14]1[cH:15][cH:16][c:17]([NH:20][C:21](=[O:22])[NH:23][c:24]3[c:25]([F:34])[cH:26][cH:27][c:28]([C:30]([F:31])([F:32])[F:33])[cH:29]3)[cH:18][cH:19]1)[c:9]([C:12]#[N:13])[c:10]2[Br:11].[O:40]=[CH:41][N:42]([CH3:43])[CH3:44]>>[NH2:1][c:2]1[n:3][cH:4][n:5][n:6]2[c:7]1[c:8](-[c:14]1[cH:15][cH:16][c:17]([NH:20][C:21](=[O:22])[NH:23][c:24]3[c:25]([F:34])[cH:26][cH:27][c:28]([C:30]([F:31])([F:32])[F:33])[cH:29]3)[cH:18][cH:19]1)[c:9]([C:12]#[N:13])[c:10]2[CH:41]=[O:40]Participants
5
Sources & evidence
- ORD record
- ord-8590cbcf9d124d79b88aac1089853250
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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