Tetrahydrofuran → {1-[Bis(4-chlorophenyl)methyl]azetidin-3-ylidene}(3,5-difluorophenyl)acetonitrile
Reaction equation
[CH2:51]1[O:52][CH2:53][CH2:54][CH2:55]1.[CH3:46][S:47](=[O:48])(=[O:49])[Cl:50].[CH3:56][N:57]([CH3:58])[c:59]1[cH:60][cH:61][n:62][cH:63][cH:64]1.[CH:37]([N:38]([CH2:39][CH3:40])[CH:41]([CH3:42])[CH3:43])([CH3:44])[CH3:45].[Cl:17][c:18]1[cH:19][cH:20][c:21]([CH:24]([N:25]2[CH2:26][C:27](=[O:29])[CH2:28]2)[c:30]2[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]2)[cH:22][cH:23]1.[F:1][c:2]1[cH:3][c:4]([CH2:9][C:10]#[N:11])[cH:5][c:6]([F:8])[cH:7]1.[Li:12][CH2:13][CH2:14][CH2:15][CH3:16]>>[F:1][c:2]1[cH:3][c:4]([C:9]([C:10]#[N:11])=[C:27]2[CH2:26][N:25]([CH:24]([c:21]3[cH:20][cH:19][c:18]([Cl:17])[cH:23][cH:22]3)[c:30]3[cH:31][cH:32][c:33]([Cl:36])[cH:34][cH:35]3)[CH2:28]2)[cH:5][c:6]([F:8])[cH:7]1Participants
8
Reactant 7
Product 1
Sources & evidence
- ORD record
- ord-297279a51228415891a2413fa7c46ddf
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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