Dichloromethane → Tert-butyl 3-[4-(2-{4-[(2,3-dihydro-indole-1-carbonyl)-amino]-3-methoxy-phenyl}-acetylamino)-phenyl]-butyrate

HRID 289450Notes

Reaction equation

HRID 289450 reaction equation
[CH2:42]1[CH2:43][c:44]2[cH:45][cH:46][cH:47][cH:48][c:49]2[NH:50]1.[CH3:54][CH2:55][N:56]([CH2:57][CH3:58])[CH2:59][CH3:60].[Cl:1][C:2]([Cl:3])([O:4][C:5]([O:6][C:7]([Cl:8])([Cl:9])[Cl:10])=[O:11])[Cl:12].[Cl:51][CH2:52][Cl:53].[NH2:13][c:14]1[c:15]([O:40][CH3:41])[cH:16][c:17]([CH2:20][C:21](=[O:22])[NH:23][c:24]2[cH:25][cH:26][c:27]([CH:30]([CH2:31][C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38])[CH3:39])[cH:28][cH:29]2)[cH:18][cH:19]1>>[C:5](=[O:11])([NH:13][c:14]1[c:15]([O:40][CH3:41])[cH:16][c:17]([CH2:20][C:21](=[O:22])[NH:23][c:24]2[cH:25][cH:26][c:27]([CH:30]([CH2:31][C:32](=[O:33])[O:34][C:35]([CH3:36])([CH3:37])[CH3:38])[CH3:39])[cH:28][cH:29]2)[cH:18][cH:19]1)[N:50]1[CH2:42][CH2:43][c:44]2[cH:45][cH:46][cH:47][cH:48][c:49]21

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 8471TriethylamineHCID 10328IndolineHCID 94429TriphosgeneHCID 22994176Tert-butyl 3-[4-({4-amino-3-methoxyphenyl}acetylamino)phenyl]butyrate

Product 1

HCID 22994266Tert-butyl 3-[4-(2-{4-[(2,3-dihydro-indole-1-carbonyl)-amino]-3-methoxy-phenyl}-acetylamino)-phenyl]-butyrate

Sources & evidence

ORD record
ord-b0efe8df27584c869330c463983631be
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…