Methanol → 4-(5-chloro-6-(2,2,2-trifluoroethoxy)-4'-(trifluoromethyl)biphenyl-3-yl)tetrahydro-2H-pyran-4-carboxylic acid
Reaction equation
[CH2:40]1[O:41][CH2:42][CH2:43][CH2:44]1.[CH3:38][OH:39].[Cl:1][c:2]1[cH:3][c:4]([C:24]2([C:30](=[O:31])[O:32][CH2:33][CH3:34])[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[cH:5][c:6](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[c:7]1[O:8][CH2:9][C:10]([F:11])([F:12])[F:13].[Li+:37].[OH-:36].[OH2:35].[OH2:45]>>[Cl:1][c:2]1[cH:3][c:4]([C:24]2([C:30](=[O:31])[OH:32])[CH2:25][CH2:26][O:27][CH2:28][CH2:29]2)[cH:5][c:6](-[c:14]2[cH:15][cH:16][c:17]([C:20]([F:21])([F:22])[F:23])[cH:18][cH:19]2)[c:7]1[O:8][CH2:9][C:10]([F:11])([F:12])[F:13]Participants
7
Sources & evidence
- ORD record
- ord-4a57c261a7ff4316826c6995f078bfa7
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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