反应详情

80 mg (0.20 mmol) of the compound obtained in Example 17 was dissolved in 1 ml of tetrahydropurane, to which 23 μl (0.20 mmol) of benzoil chloride and 42 μl (0.30 mmol) of triethylamine were added. They were reacted at room temperature for 1 hour. Then, 10 ml of saturated NaHCO3 solution was added and extraction was performed with 30 ml of ethyl acetate. Organic layer was washed with brine and dried over anhydrous MgSO4, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1), to give 93 mg (yield: 92%) of the target compound.

1. additionwere added
2. customThey were reacted at room temperature for 1 hour
3. extractionextraction
4. washOrganic layer was washed with brine
5. dry with materialdried over anhydrous MgSO4
6. concentrationconcentrated under reduced pressure
7. customThe residue was purified by silica gel column chromatography (hexane:ethyl acetate=2:1)