反应详情

To a solution of 2-phenylethylamine (72 mL, 570 mmol) is added K2CO3 (82 g, 570 mmol) and 4-bromo-1-butene (25 g, 185 mmol). The solution is stirred overnight at room temperature. The solution is evaporated to dryness and H2O/EtOAc (1:1) (600 mL) is added. The mixture is extracted with EtOAc (4×150 mL). The organic extracts are combined, dried and concentrated under vacuum. The residue is purified by flash chromatography (silica gel; Hexane/EtOAc 1:8) to provide 20 g (62%) of the title compound. M+H+=176.10.

1. customThe solution is evaporated to dryness and H2O/EtOAc (1:1) (600 mL)
2. additionis added
3. extractionThe mixture is extracted with EtOAc (4×150 mL)
4. customdried
5. concentrationconcentrated under vacuum
6. customThe residue is purified by flash chromatography (silica gel; Hexane/EtOAc 1:8)