反应详情

4-Hydroxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester (200 mg) was mixed with ethyl iodide (0.5 mL), K2CO3 (200 mg) and 2 mL of DMF. The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate layers were washed with brine. Removal of the solvent under vacuum gave the crude product, which was purified by column chromatography to give 175 mg (77% yield) of 4-ethoxy-3-methyl-benzofuran-2-carboxylic acid ethyl ester as white solid.

1. washThe mixture was washed with brine
2. extractionextracted with ethyl acetate
3. washThe combined ethyl acetate layers were washed with brine
4. customRemoval of the solvent under vacuum
5. customgave the crude product, which
6. customwas purified by column chromatography