Acetone → 2-(2-nitrophenyl)-Thiazolo[5,4-b]pyridine-6-methanol

HRID 293455Notes

Reaction equation

HRID 293455 reaction equation
[Al+3:24].[CH2:39]1[O:40][CH2:41][CH2:42][CH2:43]1.[CH3:29][C:30](=[O:31])[CH3:32].[Cl:44][CH2:45][Cl:46].[H-:23].[H-:26].[H-:27].[H-:28].[Li+:25].[N+:1](=[O:2])([O-:3])[c:4]1[c:5](-[c:10]2[s:11][c:12]3[n:13][cH:14][c:15]([C:19](=[O:20])[O:21][CH3:22])[cH:16][c:17]3[n:18]2)[cH:6][cH:7][cH:8][cH:9]1.[Na+:37].[Na+:38].[S:33]([O-:34])([O-:35])=[O:36]>>[N+:1](=[O:2])([O-:3])[c:4]1[c:5](-[c:10]2[s:11][c:12]3[n:13][cH:14][c:15]([CH2:19][OH:20])[cH:16][c:17]3[n:18]2)[cH:6][cH:7][cH:8][cH:9]1

Participants

10

Reactant 9

HCID 180AcetoneHCID 923Sodium ion2×HCID 1099SulfiteHCID 6344DichloromethaneHCID 8028TetrahydrofuranHCID 28486Lithium ionHCID 104727Aluminum CationHCID 166653Hydride4×HCID 58551887Methyl 2-(2-nitrophenyl)thiazolo[5,4-b]pyridine-6-carboxylate

Product 1

HCID 573471802-(2-nitrophenyl)-Thiazolo[5,4-b]pyridine-6-methanol

Sources & evidence

ORD record
ord-29ba4d5426d04bae963b0b6383a68500
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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