反应详情

To 4-hydroxy-3-methyl-benzofuran-2-carboxylic acid tert-butyl ester (200 mg, 0.8 mmol) in 4 mL of DMF was added 2-bromopropane (0.5 mL), and K2CO3 (200 mg). The mixture was stirred at room temperature overnight. The mixture was washed with brine and extracted with ethyl acetate. The combined ethyl acetate layers were washed with brine. Removal of the solvent gave 176 mg of 3-methyl-4-isopropoxy-benzofuran-2-carboxylic acid tert-butyl ester as colorless crystals.

1. washThe mixture was washed with brine
2. extractionextracted with ethyl acetate
3. washThe combined ethyl acetate layers were washed with brine
4. customRemoval of the solvent