Bicarbonate Ion → N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-6-ethyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

HRID 294094Notes

Reaction equation

HRID 294094 reaction equation
[C:76](=[O:77])([O-:78])[OH:79].[CH2:25]([CH3:26])[c:27]1[cH:28][cH:29][c:30]([C:40](=[O:41])[OH:42])[c:31](=[O:39])[n:32]1-[c:33]1[cH:34][cH:35][cH:36][cH:37][cH:38]1.[CH3:81][N:82]([CH3:83])[CH:84]=[O:85].[CH3:86][CH2:87][O:88][C:89](=[O:90])[CH3:91].[CH:67]([N:68]([CH2:69][CH3:70])[CH:71]([CH3:72])[CH3:73])([CH3:74])[CH3:75].[NH2:1][c:2]1[cH:3][c:4]([F:24])[c:5]([O:6][c:7]2[cH:8][cH:9][c:10]3[n:11]([cH:12]2)[cH:13][c:14]([NH:16][C:17](=[O:18])[CH:19]2[CH2:20][CH2:21]2)[n:15]3)[cH:22][cH:23]1.[Na+:80].[P-:43]([F:44])([F:45])([F:46])([F:47])([F:48])[F:49].[n:50]1([O:51][C:52]([N:53]([CH3:54])[CH3:55])=[N+:56]([CH3:57])[CH3:58])[c:59]2[n:60][cH:61][cH:62][cH:63][c:64]2[n:65][n:66]1>>[NH:1]([c:2]1[cH:3][c:4]([F:24])[c:5]([O:6][c:7]2[cH:8][cH:9][c:10]3[n:11]([cH:12]2)[cH:13][c:14]([NH:16][C:17](=[O:18])[CH:19]2[CH2:20][CH2:21]2)[n:15]3)[cH:22][cH:23]1)[C:40]([c:30]1[cH:29][cH:28][c:27]([CH2:25][CH3:26])[n:32](-[c:33]2[cH:34][cH:35][cH:36][cH:37][cH:38]2)[c:31]1=[O:39])=[O:41]

Participants

10

Reactant 9

HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 581585696-Ethyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxylic acidHCID 58158605N-[6-(4-amino-2-fluorophenoxy)imidazo[1,2-a]pyridin-2-yl]cyclopropanecarboxamide

Product 1

HCID 58158510N-[4-({2-[(cyclopropylcarbonyl)amino]imidazo[1,2-a]pyridin-6-yl}oxy)-3-fluorophenyl]-6-ethyl-2-oxo-1-phenyl-1,2-dihydropyridine-3-carboxamide

Sources & evidence

ORD record
ord-faafaabe32544490a1514de656fd1340
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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