Water → 4-Chloro-2-(trifluoromethyl)nicotinic acid
Reaction equation
[CH2:11]([Li:12])[CH2:13][CH2:14][CH3:15].[CH2:37]1[O:38][CH2:39][CH2:40][CH2:41]1.[CH3:1][C:2]1([CH3:3])[CH2:4][CH2:5][CH2:6][C:7]([CH3:8])([CH3:9])[NH:10]1.[Cl:29][C:30]([C:31]([Cl:32])([Cl:33])[Cl:34])([Cl:35])[Cl:36].[F:16][C:17]([c:18]1[c:19]([C:20](=[O:21])[OH:22])[cH:23][cH:24][cH:25][n:26]1)([F:27])[F:28].[OH2:42].[cH:43]1[cH:44][cH:45][n:46][cH:47][cH:48]1>>[F:16][C:17]([c:18]1[c:19]([C:20](=[O:21])[OH:22])[c:23]([Cl:29])[cH:24][cH:25][n:26]1)([F:27])[F:28]Participants
8
Sources & evidence
- ORD record
- ord-f0263b5d3f33415688574b50cbe9a5bd
- Source dataset
- Training data from https://doi.org/10.1039/C8SC04228D (8/10)
Reaction notes
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