Acetate → tert-butyl 6-(3-methoxy-3-oxoprop-1-enyl)-4-oxospiro[3H-1,3-benzoxazine-2,4'-piperidine]-1'-carboxylate

HRID 297725Notes

Reaction equation

HRID 297725 reaction equation
[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([O:12][c:13]3[c:14]([cH:18][c:19]([Br:22])[cH:20][cH:21]3)[C:15](=[O:17])[NH:16]2)[CH2:23][CH2:24]1.[C:47]([CH:48]=[CH2:49])(=[O:50])[O:51][CH3:52].[O-:59][C:60]([CH3:61])=[O:62].[O-:63][C:64]([CH3:65])=[O:66].[O:53]=[CH:54][N:55]([CH3:56])[CH3:57].[Pd+2:58].[c:25]1([CH3:26])[cH:27][cH:28][cH:29][cH:30][c:31]1[P:32]([c:33]1[cH:34][cH:35][cH:36][cH:37][c:38]1[CH3:39])[c:40]1[cH:41][cH:42][cH:43][cH:44][c:45]1[CH3:46]>>[C:1]([CH3:2])([CH3:3])([CH3:4])[O:5][C:6](=[O:7])[N:8]1[CH2:9][CH2:10][C:11]2([O:12][c:13]3[c:14]([cH:18][c:19]([CH:49]=[CH:48][C:47](=[O:50])[O:51][CH3:52])[cH:20][cH:21]3)[C:15](=[O:17])[NH:16]2)[CH2:23][CH2:24]1

Participants

7

Reactant 6

HCID 175Acetate2×HCID 6228DimethylformamideHCID 7294Methyl AcrylateHCID 80271Tri-o-tolylphosphineHCID 105144Allyl(1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene)chloropalladium(II)HCID 2794762tert-Butyl 6-bromo-4-oxo-3,4-dihydro-1'H-spiro[1,3-benzoxazine-2,4'-piperidine]-1'-carboxylate

Product 1

HCID 66932323tert-butyl 6-(3-methoxy-3-oxoprop-1-enyl)-4-oxospiro[3H-1,3-benzoxazine-2,4'-piperidine]-1'-carboxylate

Sources & evidence

ORD record
ord-27a42d842161417e9430949cfccff15a
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…