N,N-Dimethylglycine → N-[4-[1-[6-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-3-yl]ethyl]phenyl]methanesulfonamide

HRID 299148Notes

Reaction equation

HRID 299148 reaction equation
[Br:1][c:2]1[cH:3][cH:4][c:5]([CH:8]([CH3:9])[N:10]2[C:11](=[O:33])[O:12][C:13]([c:16]3[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]3)([CH2:23][CH2:24][O:25][Si:26]([CH3:27])([CH3:28])[C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:14][CH2:15]2)[cH:6][cH:7]1.[CH3:34][S:35](=[O:36])(=[O:37])[NH2:38].[CH3:47][N:48]([CH2:49][C:50](=[O:51])[OH:52])[CH3:53].[CH3:59][CH2:60][O:61][C:62]([CH3:63])=[O:64].[Cu:65][I:66].[K+:44].[K+:45].[K+:46].[O:54]=[CH:55][N:56]([CH3:57])[CH3:58].[P:39]([O-:40])([O-:41])([O-:42])=[O:43]>>[c:2]1([NH:38][S:35]([CH3:34])(=[O:36])=[O:37])[cH:3][cH:4][c:5]([CH:8]([CH3:9])[N:10]2[C:11](=[O:33])[O:12][C:13]([c:16]3[cH:17][cH:18][c:19]([F:22])[cH:20][cH:21]3)([CH2:23][CH2:24][O:25][Si:26]([CH3:27])([CH3:28])[C:29]([CH3:30])([CH3:31])[CH3:32])[CH2:14][CH2:15]2)[cH:6][cH:7]1

Participants

9

Reactant 8

HCID 673N,N-DimethylglycineHCID 813Potassium Cation3×HCID 1061PhosphateHCID 6228DimethylformamideHCID 8857Ethyl AcetateHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 72879MethanesulfonamideHCID 178435650HCID 178435650, compound

Product 1

HCID 123192051N-[4-[1-[6-[2-[tert-butyl(dimethyl)silyl]oxyethyl]-6-(4-fluorophenyl)-2-oxo-1,3-oxazinan-3-yl]ethyl]phenyl]methanesulfonamide

Sources & evidence

ORD record
ord-40c4c910a196475ea19330dd1e061e82
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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