Dimethylformamide → tert-butyl N-[7a-[2-fluoro-5-[(5-fluoropyridine-2-carbonyl)amino]phenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

HRID 299759Notes

Reaction equation

HRID 299759 reaction equation
[CH:60]([N:61]([CH2:62][CH3:63])[CH:64]([CH3:65])[CH3:66])([CH3:67])[CH3:68].[F:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[O:9])[OH:10])[n:6][cH:7]1.[NH2:11][c:12]1[cH:13][cH:14][c:15]([F:35])[c:16]([C:18]23[N:19]=[C:20]([NH:27][C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[S:21][CH2:22][CH:23]2[CH2:24][CH2:25][O:26]3)[cH:17]1.[O:69]=[CH:70][N:71]([CH3:72])[CH3:73].[P-:36]([F:37])([F:38])([F:39])([F:40])([F:41])[F:42].[n:43]1([O:44][C:45]([N:46]([CH3:47])[CH3:48])=[N+:49]([CH3:50])[CH3:51])[c:52]2[n:53][cH:54][cH:55][cH:56][c:57]2[n:58][n:59]1>>[F:1][c:2]1[cH:3][cH:4][c:5]([C:8](=[O:10])[NH:11][c:12]2[cH:13][cH:14][c:15]([F:35])[c:16]([C:18]34[N:19]=[C:20]([NH:27][C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[S:21][CH2:22][CH:23]3[CH2:24][CH2:25][O:26]4)[cH:17]2)[n:6][cH:7]1

Participants

7

Reactant 6

HCID 6228DimethylformamideHCID 9886HexafluorophosphateHCID 81531DiisopropylethylamineHCID 27628765-fluoropyridine-2-carboxylic AcidHCID 4641409(Dimethylamino)-N,N-dimethyl(3H-(1,2,3)triazolo(4,5-b)pyridin-3-yloxy)methaniminiumHCID 123188868tert-butyl N-[7a-(5-amino-2-fluorophenyl)-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

Product 1

HCID 123155127tert-butyl N-[7a-[2-fluoro-5-[(5-fluoropyridine-2-carbonyl)amino]phenyl]-4,4a,5,6-tetrahydrofuro[2,3-d][1,3]thiazin-2-yl]carbamate

Sources & evidence

ORD record
ord-ab680399ab8c4f4a98a2cdd405c828e9
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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