Dimethylformamide → 1-(7-bromo-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(4-(pyridin-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethane-1,2-dione

HRID 300301Notes

Reaction equation

HRID 300301 reaction equation
[B-:50]([F:51])([F:52])([F:53])[F:54].[Br:1][c:2]1[n:3][cH:4][c:5]([O:16][CH3:17])[c:6]2[c:7]1[nH:8][cH:9][c:10]2[C:11]([C:12](=[O:13])[OH:14])=[O:15].[CH:41]([N:42]([CH2:43][CH3:44])[CH:45]([CH3:46])[CH3:47])([CH3:48])[CH3:49].[F:34][C:35]([F:36])([F:37])[C:38]([OH:39])=[O:40].[O:72]=[CH:73][N:74]([CH3:75])[CH3:76].[n:18]1[c:19](-[c:24]2[c:25]3[c:26]([n:27][cH:28][n:29]2)[CH2:30][NH:31][CH2:32][CH2:33]3)[cH:20][cH:21][cH:22][cH:23]1.[n:55]1([O:56][C:57]([N:58]([CH3:59])[CH3:60])=[N+:61]([CH3:62])[CH3:63])[c:64]2[cH:65][cH:66][cH:67][cH:68][c:69]2[n:70][n:71]1>>[Br:1][c:2]1[n:3][cH:4][c:5]([O:16][CH3:17])[c:6]2[c:7]1[nH:8][cH:9][c:10]2[C:11]([C:12](=[O:14])[N:31]1[CH2:30][c:26]2[c:25]([c:24](-[c:19]3[n:18][cH:23][cH:22][cH:21][cH:20]3)[n:29][cH:28][n:27]2)[CH2:33][CH2:32]1)=[O:15]

Participants

8

Reactant 7

HCID 6228DimethylformamideHCID 6422Trifluoroacetic acidHCID 26255TetrafluoroborateHCID 81531DiisopropylethylamineHCID 130500O-benzotriazol-1-yl-tetramethyluroniumHCID 575904977-Bromo-4-methoxy-α-oxo-1H-pyrrolo[2,3-c]pyridine-3-acetic acidHCID 580260644-(Pyridin-2-yl)-5,6,7,8-tetrahydropyrido[3,4-d]pyrimidine

Product 1

HCID 580260381-(7-bromo-4-methoxy-1H-pyrrolo[2,3-c]pyridin-3-yl)-2-(4-(pyridin-2-yl)-5,6-dihydropyrido[3,4-d]pyrimidin-7(8H)-yl)ethane-1,2-dione

Sources & evidence

ORD record
ord-cafc8788ed164ce3ba6abde8d3d65d77
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

Loading…