Hydrochloric Acid → N-{4-[2-(1-Acetylpiperidin-4-yl)-4-(3-chlorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide

HRID 300971Notes

Reaction equation

HRID 300971 reaction equation
[C:42](=[O:43])([O-:44])[OH:45].[CH3:31][C:32]([Cl:33])=[O:34].[CH3:35][CH2:36][N:37]([CH2:38][CH3:39])[CH2:40][CH3:41].[Cl:3][c:4]1[cH:5][c:6](-[c:10]2[n:11][c:12]([CH:25]3[CH2:26][CH2:27][NH:28][CH2:29][CH2:30]3)[s:13][c:14]2-[c:15]2[cH:16][c:17]([NH:21][C:22]([CH3:23])=[O:24])[n:18][cH:19][cH:20]2)[cH:7][cH:8][cH:9]1.[ClH:1].[ClH:2].[Na+:46].[O:47]1[CH2:48][CH2:49][CH2:50][CH2:51]1>>[Cl:3][c:4]1[cH:5][c:6](-[c:10]2[n:11][c:12]([CH:25]3[CH2:26][CH2:27][N:28]([C:32]([CH3:31])=[O:34])[CH2:29][CH2:30]3)[s:13][c:14]2-[c:15]2[cH:16][c:17]([NH:21][C:22]([CH3:23])=[O:24])[n:18][cH:19][cH:20]2)[cH:7][cH:8][cH:9]1

Participants

8

Reactant 7

HCID 313Hydrochloric Acid2×HCID 769Bicarbonate IonHCID 923Sodium ionHCID 6367Acetyl chlorideHCID 8028TetrahydrofuranHCID 8471TriethylamineHCID 68827429HCID 68827429, compound

Product 1

HCID 53432114N-{4-[2-(1-Acetylpiperidin-4-yl)-4-(3-chlorophenyl)-1,3-thiazol-5-yl]pyridin-2-yl}acetamide

Sources & evidence

ORD record
ord-836c9e838d104eb6875decf750b1ddef
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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