Dimethylformamide → 5-Aminopyrazine-2-carbonitrile

HRID 301457Notes

Reaction equation

HRID 301457 reaction equation
[Br:1][c:2]1[n:3][cH:4][c:5]([NH2:8])[n:6][cH:7]1.[Cu:35][I:36].[K:9][C:10]#[N:11].[O:12]1[CH2:13][CH2:14][O:15][CH2:16][CH2:17][O:18][CH2:19][CH2:20][O:21][CH2:22][CH2:23][O:24][CH2:25][CH2:26][O:27][CH2:28][CH2:29]1.[O:30]=[CH:31][N:32]([CH3:33])[CH3:34]>>[c:2]1([C:10]#[N:11])[n:3][cH:4][c:5]([NH2:8])[n:6][cH:7]1

Participants

6

Reactant 5

HCID 6228DimethylformamideHCID 24350Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI)HCID 2855718-Crown-6HCID 5995392-Amino-5-bromopyrazineHCID 178511842HCID 178511842, compound

Product 1

HCID 139252945-Aminopyrazine-2-carbonitrile

Sources & evidence

ORD record
ord-0108527eb9034686ac974cc8f38c4fd4
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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