Benzaldehyde → Methyl 1-benzylpiperidine-2-carboxylate

HRID 301695Notes

Reaction equation

HRID 301695 reaction equation
[C:29]([O:30][BH-:31]([O:32][C:33](=[O:34])[CH3:35])[O:36][C:37](=[O:38])[CH3:39])(=[O:40])[CH3:41].[C:43](=[O:44])([O-:45])[OH:46].[CH3:2][O:3][C:4](=[O:5])[CH:6]1[NH:7][CH2:8][CH2:9][CH2:10][CH2:11]1.[CH:12]([N:13]([CH2:14][CH3:15])[CH:16]([CH3:17])[CH3:18])([CH3:19])[CH3:20].[CH:21](=[O:22])[c:23]1[cH:24][cH:25][cH:26][cH:27][cH:28]1.[Cl:48][CH2:49][Cl:50].[ClH:1].[Na+:42].[Na+:47]>>[CH3:2][O:3][C:4](=[O:5])[CH:6]1[N:7]([CH2:21][c:23]2[cH:24][cH:25][cH:26][cH:27][cH:28]2)[CH2:8][CH2:9][CH2:10][CH2:11]1

Participants

9

Reactant 8

HCID 240BenzaldehydeHCID 313Hydrochloric AcidHCID 769Bicarbonate IonHCID 923Sodium ion2×HCID 6344DichloromethaneHCID 81531DiisopropylethylamineHCID 2724942TriacetoxyborohydrideHCID 3463753Methyl pipecolinate

Product 1

HCID 10443988Methyl 1-benzylpiperidine-2-carboxylate

Sources & evidence

ORD record
ord-54fe4ead200749f5bb709f3347b08feb
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (8/10)

Reaction notes

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