反应详情

温度

95 °C

To a mixture of 2-chlorothiophene (0.248 mL, 2.68 mmol), tert-butyl piperazine-1-carboxylate (500 mg, 2.68 mmol), and TEA (1.123 mL, 8.05 mmol) in DMF (4 mL) was added Pd(Ph3P)4 (57.8 mg, .05 mmol). The reaction was allowed to heat at 95 °C for overnight. LCMS and TLC showed the starting material peak as well as the triphenyl phosphene ionized M+1 peak. The tryphenyl phosphene showed up at the same retention time as 2-chlorothiophene. No new peak was observed following the reaction so no purification techniques were run. MS (m+1) = not seen